The five hindrances (pañcanivarana) are sensual desire, ill will, sloth and
torpor, restlessness and worry, and doubt. This group, the principal
classification the Buddha uses for the obstacles to meditation, receives its
name because its five members hinder and envelop the mind, preventing
meditative development in the two spheres of serenity and insight. Hence the
Buddha calls them "obstructions, hindrances, corruptions of the mind which
weaken wisdom"(S.v,94).
...
Once he has fulfilled these preliminaries the disciple is prepared to go into
solitude to develop the jhanas, and it is here that he directly confronts the
five hindrances. The elimination of the hindrances requires that the meditator
honestly appraises his own mind. When sensuality, ill will and the other
hindrances are present, he must recognize that they are present and he must
investigate the conditions that lead to their arising: the latter he must
scrupulously avoid.(??????) The meditator must also understand the appropriate
antidotes for each of the five hindrances. The Buddha says that all the
hindrances arise through unwise consideration (ayoniso manasikara) and that
they can be eliminated by wise consideration (yoniso manasikara). Each
hindrance, however, has its own specific antidote. Thus wise consideration of
the repulsive feature of things is the antidote to sensual desire; wise
consideration of loving-kindness counteracts ill will; wise consideration of the
elements of effort, exertion and striving opposes sloth and torpor; wise
consideration of tranquillity of mind removes restlessness and worry; and
wise consideration of the real qualities of things eliminates doubt (S.v,105-
106).

In the last paragragh Gunaratana talked about the antidotes for the hindrances? How and when can I apply them? (During samatha practice?)

I would really appreciate some thoughts on this topic. How did you solve this problem?

Questions, Questions, Questions,... =) I would be very grateful for some answers, because questions like these tickle and sting me during my practice and that distracts me.

It might help us to know which hindrances you are having trouble with. 1) And what have you tried that has not worked. 2) Are there any hindrances that are playing havoc with your ability to meditate?

3)Generally speaking, the establishment of mindfulness (and bare attention to this very moment) before embarking on meditation is always helpful with regard to combating the hindrances.

1) If you are using jhanas to keep the hindrances at bay then you have to keep applying attention and sustaining it long enough for this to happen:

Jhana factors

Jhana Factors
1. Applied Thought eliminates Drowsiness and laziness
2. Sustained thought eliminates Doubt,
3. Joy or Rapture eliminates Ill Will,
4. Peaceful Happiness eliminates Restlessness
5. One-pointed Concentration eliminates Sensual Desire.

2) Eventually you should turn to insight practice where you don't force thoughtlessness and just pay attention to hindrances arising and passing away on their own accord. You just have to pay attention to it/not cling with obsessive thoughts and let the mind quiet on it's own. In the end it's more efficient but I started with jhanas first.