First of all, there is no such disease as "chronic Lyme disease". No serious doctor who respects the evidence based medicine can diagnose this nonsense. But there are quack doctors associated mainly with pseudoscientific activist organisation "The International Lyme and Associated Diseases Society" which promotes many bogus claims like that it is necessary to abuse combination of various antibiotics chronically for several months to several years to eradicate imagined bacteria.
The correct scientific view on this tick born disease is presented by "The Infectious Diseases Society of America".
The problem is that there are many patients suffering from extremely serious, harrowing and debilitating diseases that current medicine can't even diagnose so far. Let alone treat them.
These patients are mocked by doctors because psychosomatic medicine is unfortunatelly still recognized as a part of medicine. And even in the ICD-10 and DSM-IV-TR there are still bogus diagnoses like "somatoform disorder", "conversion disorder", "neurastenia" and other non sequitur diagnoses that are not based on evidence but on the absence of evidence.
These patients suffering from unrecognized serious, chronic and heart-breaking diseases are desperate and so they opt for seemingly more rational solution: Eradicate "pathogens" by taking large amounts of antibiotics. After all for them it makes more sense than to think that they have been for years or decades so profoundly debilitated because of some arcane "suppressed childhood emotional traumas", because of "stress", some "wrong mental patterns", "false beliefs and deconditiong", "psychogenic causes" and all the other intellectual garbage produced and invented by the psychosomatic experts.
In fact these patients can indeed notice some real improvement since many antibiotics have antiinflamatory effects, inhibit glial activation, some block serotonin or dopamine transporter etc.
And now to your main question: Fatigue is probably the single most common symptom of all diseases, be they known ones or so far unknown ones. The next most often symptom is probably pain. There is even a diagnosis with an extremely ridiculous name "chronic fatigue syndrome". Now it turns out that a better name for this disease is "myalgic encephalomyelitis" and during the last three years some first serious research of this incapacitating and life long disease has been conducted at last. The scientific community slowly begins to realize that chronic fatigue syndrome probably represents the single most important mystery or problem in biomedical research and institutions like NIH gives substantial grant money and establishes research institutions to solve this disease(s).
Be it asi it may, I think that meditation can help you a lot. Be strong, brave and patient!